21c Museum Hotels is set to begin the renovation and restoration of downtown St. Louis’ historic YMCA building.

Construction of 21c Museum Hotel St. Louis is expected to be completed in the fourth quarter of 2022. The project includes a 173-room boutique hotel, contemporary art museum, wellness center, meeting and event space and multiple food and beverage outlets.

21c St. Louis will be housed in the 10-story, Renaissance Revival-style YMCA building. Architects Perfido Weiskopf Wagstaf + Goettel are working with interior designers from Hufft Projects and Bill Rooney Studio to refresh the 95-year-old building into a contemporary space that pays homage to its historic roots. St. Louis-based Russell HBD will manage construction on the project.