With a combined 288 rooms and suites, this is the first combination of the AC Hotels by Marriott and Moxy Hotels brands under one roof.
The downtown Tampa, Fla., project will include a new-build 230-room Hyatt Place and a 115-room Hyatt House.
Building on an existing partnership, the new deal will see the group grow its portfolio in the country to six hotels and almost 1,000 rooms by 2025.
IHG acquired the wellness brand from private equity fund Pegasus Capital Advisors for $300 million.
Across the Middle East and North Africa, hotels have seen only six months of profit growth over the past two years, according to HotStats.
Matt Luscombe has nearly 20 years of hospitality and consumer experience, including a decade with IHG.
The new hotels opened in Mesquite, Texas; Bardstown, Ky.; and Santa Monica and Hollister, Calif.
Shutters on the Beach and Hotel Casa del Mar, two neighboring hotels in Santa Monica, add more than 300 guestrooms to Preferred's portfolio.
This achievement coincides with the one-year anniversary of Choice Hotels' acquisition of the WoodSpring brand and franchise business.
The move by the New Mexico-based hotel-management company streamlines data management and budgeting and forecasting operations.